General Information:

Id: 985 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
Tg2576 mouse model
article
Reference: Chauhan NB(2006) Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimers transgenic model Tg2576 J Ethnopharmacol 108: 385-394 [PMID: 16842945]

Interaction Information:

Comment Aged garlic extract and its constituents SAC (S-allyl-cysteine) and DADS (di-allyl-disulfide) reduced cerebral plaques, reduced detergent soluble and detergent resistant (fibrillar) Abeta-species with increased alpha-cleaved sAPPalpha, reduced cerebral inflammation and phosphorylation-induced conformational change in tau protein.
Formal Description
Interaction-ID: 6136

drug/chemical compound

S-allyl-cysteine

decreases_activity of