General Information:

Id: 981
Diseases: Parkinson disease
Mus musculus
BTO:0004102 cerebral cortical neuron
article
Reference: Gan L et al.(2010) Keap1-Nrf2 activation in the presence and absence of DJ-1 Eur. J. Neurosci. 31: 967-977 [PMID: 20377612]

Interaction Information:

Comment After tBHQ treatment for 4 and 8 h Nrf2 protein increased in the nuclear fraction of WT and KO cultures. The extent of nuclear localization was uneffected by the lack of DJ-1.
Formal Description
Interaction-ID: 6084

drug/chemical compound

TBHQ

increases_quantity of

gene/protein

NFE2L2

in nucleus
Comment After tBHQ treatment for 4 and 8 h Nrf2 protein increased in the nuclear fraction of WT and KO cultures. The extent of nuclear localization was uneffected by the lack of DJ-1.
Formal Description
Interaction-ID: 6088

gene/protein

PARK7

NOT affects_quantity of

gene/protein

NFE2L2

in nucleus; after tBHQ-treatment
Drugbank entries Show/Hide entries for PARK7
Comment Protein level of NQO1 increased more than two-fold in WT and KO cultures following a 48-h tBHQ treatment. Significant increases were also observed in the protein levels of GCLC and GCLM. Keap1 protein expression was not affected by tBHQ treatment.
Formal Description
Interaction-ID: 6089

drug/chemical compound

TBHQ

increases_quantity of

gene/protein

NQO1

Drugbank entries Show/Hide entries for NQO1
Comment Protein level of NQO1 increased more than two-fold in WT and KO cultures following a 48-h tBHQ treatment. Significant increases were also observed in the protein levels of GCLC and GCLM. Keap1 protein expression was not affected by tBHQ treatment.
Formal Description
Interaction-ID: 6090

drug/chemical compound

TBHQ

increases_quantity of

gene/protein

GCLC

Drugbank entries Show/Hide entries for GCLC
Comment Protein level of NQO1 increased more than two-fold in WT and KO cultures following a 48-h tBHQ treatment. Significant increases were also observed in the protein levels of GCLC and GCLM. Keap1 protein expression was not affected by tBHQ treatment.
Formal Description
Interaction-ID: 6091

drug/chemical compound

TBHQ

increases_quantity of

gene/protein

GCLM

Drugbank entries Show/Hide entries for GCLM
Comment Protein level of NQO1 increased more than two-fold in WT and KO cultures following a 48-h tBHQ treatment. Significant increases were also observed in the protein levels of GCLC and GCLM. Keap1 protein expression was not affected by tBHQ treatment.
Formal Description
Interaction-ID: 6092

drug/chemical compound

TBHQ

NOT increases_quantity of

gene/protein

KEAP1

Comment Nrf2 activation by tBHQ treatment protected both DJ-1-WT and DJ-1-KO cortical neuronal cultures from oxidative stress-induced cell death.
Formal Description
Interaction-ID: 6093

drug/chemical compound

TBHQ

decreases_activity of

process

neuron death

induced by oxidative stress
Comment Neuronal cultures from DJ-1 KO mice were more sensitive to oxidative stress-mediated toxicity than were neurons from WT mice.
Formal Description
Interaction-ID: 6094

gene/protein

PARK7

decreases_activity of

process

neuron death

induced by oxidative stress
Drugbank entries Show/Hide entries for PARK7
Comment Overexpression of Nrf2 selectively in astrocytes protected neighboring neurons in primary cortical cultures. These findings indicate that activation Nrf2 is a potential therapeutic target to prevent neurodegeneration.
Formal Description
Interaction-ID: 6095

gene/protein

NFE2L2

decreases_activity of

process

neuron death

in astrocytes; induced by oxidative stress, irrespectively of the presence or absence of DJ-1