General Information:

Id: 98
Diseases: Amyotrophic lateral sclerosis
Mus musculus
BTO:0000078 microglia
article
Reference: Zhao W et al.(2010) Extracellular mutant SOD1 induces microglial-mediated motoneuron injury Glia 58: 231-243 [PMID: 19672969]

Interaction Information:

Comment Extracellular mutant superoxide dismutase mSOD1(G93A) or mSOD1(G85R) did induce the morphological and functional activation of microglia, increasing their release of pro-inflammatory cytokines and free radicals.
Formal Description
Interaction-ID: 319

gene/protein mutant

SOD1-p.G93A

increases_activity of

in microglia cultures
Comment Extracellular mutant superoxide dismutase mSOD1(G93A) or mSOD1(G85R) did induce the morphological and functional activation of microglia, increasing their release of pro-inflammatory cytokines and free radicals.
Formal Description
Interaction-ID: 320

gene/protein mutant

SOD1-p.G85R

increases_activity of

in microglia cultures
Comment Extracellular mutant mSOD1 (G93A) increased microglial production of TNF-alpha in both a dose- and time-dependent manner.
Formal Description
Interaction-ID: 321

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

TNF

in microglia cultures
Drugbank entries Show/Hide entries for TNF
Comment Extracellular mutant mSOD1 (G93A) increased microglial production of IL-1-beta.
Formal Description
Interaction-ID: 323

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

IL1B

in microglia cultures
Drugbank entries Show/Hide entries for IL1B
Comment Extracellular mutant mSOD1 (G93A) induced the microglial upregulation of NOX2 mRNA.
Formal Description
Interaction-ID: 324

gene/protein mutant

SOD1-p.G93A

increases_expression of

gene/protein

CYBB

in microglia cultures
Comment Extracellular mutant mSOD1 (G93A) induced the microglial upregulation of iNOS mRNA.
Formal Description
Interaction-ID: 325

gene/protein mutant

SOD1-p.G93A

increases_expression of

gene/protein

NOS2

in microglia cultures
Drugbank entries Show/Hide entries for NOS2
Comment Extracellular mutant mSOD1 (G93A) reduced microglial IGF-1 production.
Formal Description
Interaction-ID: 326

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

IGF1

in microglia cultures
Drugbank entries Show/Hide entries for IGF1
Comment Extracellular mutant mSOD1 (G85R) induced the microglial upregulation of NOX2 mRNA.
Formal Description
Interaction-ID: 327

gene/protein mutant

SOD1-p.G85R

increases_expression of

gene/protein

CYBB

in microglia cultures
Comment Extracellular mutant mSOD1 (G85R) induced the microglial upregulation of iNOS mRNA.
Formal Description
Interaction-ID: 328

gene/protein mutant

SOD1-p.G85R

increases_expression of

gene/protein

NOS2

in microglia cultures
Drugbank entries Show/Hide entries for NOS2
Comment Extracellular mutant mSOD1 (G93A) produced more superoxide than untreated or SOD1(WT)-treated microglia.
Formal Description
Interaction-ID: 329

gene/protein mutant

SOD1-p.G93A

increases_quantity of

drug/chemical compound

O2-

in microglia cultures
Comment mSOD1(G93A) interacts with CD14. The results showed a stronger interaction between CD14 and mSOD1(G93A) than CD14 and SOD1(WT).
Formal Description
Interaction-ID: 331

gene/protein mutant

SOD1-p.G93A

interacts (colocalizes) with

gene/protein

CD14

Comment mSOD1(WT) interacts with CD14. The results showed a stronger interaction between CD14 and mSOD1(G93A) than CD14 and SOD1(WT).
Formal Description
Interaction-ID: 333

gene/protein

SOD1

interacts (colocalizes) with

gene/protein

CD14

Drugbank entries Show/Hide entries for SOD1
Comment CD14 is involved in the extracellular mSOD1(G93A)-induced microglial neurotoxicity.
Formal Description
Interaction-ID: 334

gene/protein

CD14

affects_activity of

induced by extracellular mSOD1(G93A)
Comment TLR2 and TLR4 participate in mSOD1(G93A)-induced microglial activation.
Formal Description
Interaction-ID: 335

gene/protein

TLR2

affects_activity of

induced by extracellular mSOD1(G93A)
Drugbank entries Show/Hide entries for TLR2
Comment TLR2 and TLR4 participate in mSOD1(G93A)-induced microglial activation.
Formal Description
Interaction-ID: 336

gene/protein

TLR4

affects_activity of

induced by extracellular mSOD1(G93A)
Drugbank entries Show/Hide entries for TLR4