General Information:
Id: | 97 |
Diseases: |
Amyotrophic lateral sclerosis
|
Mus musculus | |
SOD1G93A transgenic mouse, transfected with human SOD1G93A, 60 days old | |
BTO:0000078 microglia | |
article | |
Reference: | Weydt P et al.(2004) Increased cytotoxic potential of microglia from ALS-transgenic mice Glia 48: 179-182 [PMID: 15378658] |
Interaction Information:
Comment | Mutant superoxide dismutase (mtSOD1, G93A) expression increases the production of TNF-alpha and attenuates IL-6-release by LPS-activated adult microglia. |
Formal Description Interaction-ID: 317 |
gene/protein mutant increases_quantity of gene/protein |
Drugbank entries | Show/Hide entries for TNF |
Comment | Mutant superoxide dismutase (mtSOD1, G93A) expression increases the production of TNF-alpha and attenuates IL-6-release by LPS-activated adult microglia. |
Formal Description Interaction-ID: 318 |
gene/protein mutant decreases_quantity of gene/protein |
Drugbank entries | Show/Hide entries for IL6 |