General Information:

Id: 979
Diseases: Parkinson disease
Homo sapiens
BTO:0001950 HuH-7 cell
article
Reference: Clements CM et al.(2006) DJ-1, a cancer- and Parkinsons disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc. Natl. Acad. Sci. U.S.A. 103 [PMID: 17015834]

Interaction Information:

Comment DJ-1 is required for Nrf2-mediated transcription of NQO1.
Formal Description
Interaction-ID: 6040

gene/protein

NFE2L2

increases_expression of

gene/protein

NQO1

in the presence of DJ-1 (PARK7)
Drugbank entries Show/Hide entries for NQO1
Comment DJ-1 is required for Nrf2-mediated transcription of NQO1.
Formal Description
Interaction-ID: 6044

gene/protein

PARK7

increases_expression of

gene/protein

NQO1

via transcription factor Nrf2
Drugbank entries Show/Hide entries for PARK7 or NQO1
Comment DJ-1 stabilizes the antioxidant transcriptional master regulator Nrf2.
Formal Description
Interaction-ID: 6045

gene/protein

PARK7

increases_quantity of

gene/protein

NFE2L2

Drugbank entries Show/Hide entries for PARK7
Comment Nrf2 associates with Keap1, which targets Nrf2 for ubiquitination, leading to proteasomal degradation.
Formal Description
Interaction-ID: 6047

gene/protein

NFE2L2

interacts (colocalizes) with

gene/protein

KEAP1

Comment Nrf2 associates with Keap1, which targets Nrf2 for ubiquitination, leading to proteasomal degradation.
Formal Description
Interaction-ID: 6050

gene/protein

KEAP1

increases_ubiquitination/sumoylation of

gene/protein

NFE2L2

Comment Nrf2 associates with Keap1, which targets Nrf2 for ubiquitination, leading to proteasomal degradation.
Formal Description
Interaction-ID: 6052

gene/protein

KEAP1

decreases_quantity of

gene/protein

NFE2L2

via ubiquitin-mediated proteasomal degradation
Comment Nrf2 was ubiquitinated to a much lesser degree when DJ-1 was overexpressed, correlating with an increase of Nrf2 protein in the presence of DJ-1.
Formal Description
Interaction-ID: 6054

gene/protein

PARK7

decreases_ubiquitination/sumoylation of

gene/protein

NFE2L2

Drugbank entries Show/Hide entries for PARK7
Comment DJ-1 stabilizes Nrf2 by preventing its association with Keap1.
Formal Description
Interaction-ID: 6062

gene/protein

PARK7

increases_quantity of

gene/protein

NFE2L2

by preventing its association with Keap1
Drugbank entries Show/Hide entries for PARK7
Comment DJ-1 is not physically associated with Nrf2, Keap1 or Cullin3.
Formal Description
Interaction-ID: 6065

gene/protein

PARK7

NOT interacts (colocalizes) with

gene/protein

NFE2L2

Drugbank entries Show/Hide entries for PARK7
Comment DJ-1 is not physically associated with Nrf2, Keap1 or Cullin3.
Formal Description
Interaction-ID: 6066

gene/protein

PARK7

NOT interacts (colocalizes) with

gene/protein

KEAP1

Drugbank entries Show/Hide entries for PARK7
Comment DJ-1 is not physically associated with Nrf2, Keap1 or Cullin3.
Formal Description
Interaction-ID: 6067

gene/protein

PARK7

NOT interacts (colocalizes) with

gene/protein

CUL3

Drugbank entries Show/Hide entries for PARK7
Comment DJ-1 stabilizes the antioxidant transcriptional master regulator Nrf2.
Formal Description
Interaction-ID: 6512

gene/protein

NFE2L2

decreases_activity of

by stabilizing antioxidant transcriptional master regulator Nrf2
Comment Nrf2 associates with Keap1, which targets Nrf2 for ubiquitination, leading to proteasomal degradation.
Formal Description
Interaction-ID: 7562

gene/protein

KEAP1

decreases_activity of

gene/protein

NFE2L2

by sequestering NRF2 in the cytoplasm