General Information:

Id: 97
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1G93A transgenic mouse, transfected with human SOD1G93A, 60 days old
BTO:0000078 microglia
article
Reference: Weydt P et al.(2004) Increased cytotoxic potential of microglia from ALS-transgenic mice Glia 48: 179-182 [PMID: 15378658]

Interaction Information:

Comment Mutant superoxide dismutase (mtSOD1, G93A) expression increases the production of TNF-alpha and attenuates IL-6-release by LPS-activated adult microglia.
Formal Description
Interaction-ID: 317

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

TNF

in adult microglia; LPS stimulated
Drugbank entries Show/Hide entries for TNF
Comment Mutant superoxide dismutase (mtSOD1, G93A) expression increases the production of TNF-alpha and attenuates IL-6-release by LPS-activated adult microglia.
Formal Description
Interaction-ID: 318

gene/protein mutant

SOD1-p.G93A

decreases_quantity of

gene/protein

IL6

in adult microglia; LPS stimulated
Drugbank entries Show/Hide entries for IL6