General Information:

Id: 9,687 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Homo sapiens
article
Reference: Lautner RQ et al.(2013) Discovery and characterization of alamandine: a novel component of the renin-angiotensin system Circ. Res. 112: 1104-1111 [PMID: 23446738]

Interaction Information:

Comment Using mass spectrometry the authors identified alamandine as a product of the catalytic hydrolysis of the octapeptide Ala1-AngII (angiotensin A) by human ACE2. They demonstrate that alamandine can be formed in the rat heart after Ang-(1–7) perfusion with the use of selected reaction monitoring-mass spectrometry. This indicates that the cardiac tissue contains all necessary components to promote the decarboxylation of the Ang-(1–7) N-terminal aspartate amino acid residue.
Formal Description
Interaction-ID: 102338

gene/protein

ACE2

increases_quantity of

gene/protein

Alamandine

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