General Information:

Id: 966 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0000093 MCF-7 cell
article
Reference: Hu P et al.(2004) Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death J. Biol. Chem. 279 [PMID: 15339911]

Interaction Information:

Comment Incubation of human breast cancer MCF-7 cells with the ER stressors thapsigargin and tunicamycin rapidly induced mRNA expression of two known UPR target genes, viz. the ER resident molecular chaperone BiP (HSPA5) and the transcription factor CHOP (DDIT3).
Formal Description
Interaction-ID: 5954

increases_expression of

gene/protein

HSPA5

Drugbank entries Show/Hide entries for HSPA5
Comment Incubation of human breast cancer MCF-7 cells with the ER stressors thapsigargin and tunicamycin rapidly induced mRNA expression of two known UPR target genes, viz. the ER resident molecular chaperone BiP and the transcription factor CHOP (DDIT3).
Formal Description
Interaction-ID: 5957

increases_expression of

gene/protein

DDIT3

Comment Incubation of human breast cancer MCF-7 cells with the ER stressors thapsigargin and tunicamycin rapidly induced mRNA expression of two known UPR target genes, viz. the ER resident molecular chaperone BiP and the transcription factor CHOP. Phosphorylation of the translation initiation factor eIF2alpha (EIF2S1) also occurred under the same conditions.
Formal Description
Interaction-ID: 5958

increases_phosphorylation of

gene/protein

EIF2S1

Comment Phosphorylation activation of Akt at Ser473 is observed at 2 h with thapsigargin and at 4 h with tunicamycin. Thapsigargin and tunicamycin are ER stressors.
Formal Description
Interaction-ID: 5960

increases_phosphorylation of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment Phosphorylation activation of Akt at Ser473 is observed at 2 h with thapsigargin and at 4 h with tunicamycin. Thapsigargin and tunicamycin are ER stressors.
Formal Description
Interaction-ID: 5963

increases_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment Incubation of human breast cancer MCF-7 cells with the ER stressors thapsigargin and tunicamycin rapidly induced the activation and phosphorylation of ERK1/2 (MAPK3 and MAPK1).
Formal Description
Interaction-ID: 5983

increases_activity of

gene/protein

MAPK3

Drugbank entries Show/Hide entries for MAPK3
Comment Incubation of human breast cancer MCF-7 cells with the ER stressors thapsigargin and tunicamycin rapidly induced the activation and phosphorylation of ERK1/2 (MAPK3 and MAPK1).
Formal Description
Interaction-ID: 5984

increases_activity of

gene/protein

MAPK1

Drugbank entries Show/Hide entries for MAPK1
Comment Incubation of human breast cancer MCF-7 cells with the ER stressors thapsigargin and tunicamycin rapidly induced the phosphorylation of JNK (MAPK8).
Formal Description
Interaction-ID: 5985

increases_phosphorylation of

gene/protein

MAPK8

Drugbank entries Show/Hide entries for MAPK8