General Information:

Id: 966 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0000093 MCF-7 cell
article
Reference: Hu P et al.(2004) Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death J. Biol. Chem. 279 [PMID: 15339911]

Interaction Information:

Comment Incubation of human breast cancer MCF-7 cells with the ER stressors thapsigargin and tunicamycin rapidly induced mRNA expression of two known UPR target genes, viz. the ER resident molecular chaperone BiP and the transcription factor CHOP. Phosphorylation of the translation initiation factor eIF2alpha (EIF2S1) also occurred under the same conditions.
Formal Description
Interaction-ID: 5958

increases_phosphorylation of

gene/protein

EIF2S1