General Information:

Id: 966 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0000093 MCF-7 cell
article
Reference: Hu P et al.(2004) Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death J. Biol. Chem. 279 [PMID: 15339911]

Interaction Information:

Comment Incubation of human breast cancer MCF-7 cells with the ER stressors thapsigargin and tunicamycin rapidly induced mRNA expression of two known UPR target genes, viz. the ER resident molecular chaperone BiP (HSPA5) and the transcription factor CHOP (DDIT3).
Formal Description
Interaction-ID: 5954

increases_expression of

gene/protein

HSPA5

Drugbank entries Show/Hide entries for HSPA5