General Information:

Id: 964 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Frojdo S et al.(2009) Alterations of insulin signaling in type 2 diabetes: a review of the current evidence from humans Biochim. Biophys. Acta 2: 83-92 [PMID: 19041393]

Interaction Information:

Comment Alterations of the activation status of the proximal insulin signaling enzymes (IR, IRS1/2, PI3K), and downstream targets (PDK, PKB and its targets GSK-3 and AS160, aPKCs, and MAPK-family protein kinases) have been studied in muscle and adipose tissue from insulin resistant, obese and type 2 diabetic subjects, and the underlying insulin resistance has been attributed to defects in one or more steps of the insulin signaling cascade.
Formal Description
Interaction-ID: 6051

affects_activity of

disease

Insulin resistance