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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	964 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance Obesity - [OMIM]
Organism:	Mammalia
Publication type:	review
Reference:	Frojdo S et al.(2009) Alterations of insulin signaling in type 2 diabetes: a review of the current evidence from humans Biochim. Biophys. Acta 2: 83-92 [PMID: 19041393]

Interaction Information:

Comment	Activated IRS1/2 recruit Grb2, which associates to SOS and activates the Erk1/2 MAPK pathway.
Formal Description Interaction-ID: 6038	gene/protein IRS1 increases_quantity of complex/PPI GRB2-SOS complex
Drugbank entries	Show/Hide entries for IRS1
Drugbank DB08513	[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENY ... not specified IRS1

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