General Information:

Id: 964 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Frojdo S et al.(2009) Alterations of insulin signaling in type 2 diabetes: a review of the current evidence from humans Biochim. Biophys. Acta 2: 83-92 [PMID: 19041393]

Interaction Information:

Comment Activated IRS1/2 recruit Grb2, which associates to SOS and activates the Erk1/2 MAPK pathway.
Formal Description
Interaction-ID: 6038

gene/protein

IRS1

increases_quantity of

complex/PPI

GRB2-SOS complex

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