CIDeRGeneral Information:
| Id: | 964 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance Obesity - [OMIM] |
| Mammalia | |
| review | |
| Reference: | Frojdo S et al.(2009) Alterations of insulin signaling in type 2 diabetes: a review of the current evidence from humans Biochim. Biophys. Acta 2: 83-92 [PMID: 19041393] |
Interaction Information:
| Comment | Mechanistically, PDK1, PKB and atypical PKCs zeta and lambda, which all contain a PH-domain, are recruited at the plasma membrane by binding to PIP3; thereon, PDK1 phosphorylates PKB and atypical PKCs zeta and lambda on a threonine residue located in the activation loop of the catalytic domain, causing their activation. |
|
Formal Description Interaction-ID: 5950 |
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| Drugbank entries | Show/Hide entries for PDPK1 or AKT1 |