General Information:

Id: 964 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Frojdo S et al.(2009) Alterations of insulin signaling in type 2 diabetes: a review of the current evidence from humans Biochim. Biophys. Acta 2: 83-92 [PMID: 19041393]

Interaction Information:

Comment Mechanistically, PDK1, PKB and atypical PKCs zeta and lambda, which all contain a PH-domain, are recruited at the plasma membrane by binding to PIP3; thereon, PDK1 phosphorylates PKB and atypical PKCs zeta and lambda on a threonine residue located in the activation loop of the catalytic domain, causing their activation.
Formal Description
Interaction-ID: 5950

gene/protein

PDPK1

increases_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for PDPK1 or AKT1