General Information:

Id: 964 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Frojdo S et al.(2009) Alterations of insulin signaling in type 2 diabetes: a review of the current evidence from humans Biochim. Biophys. Acta 2: 83-92 [PMID: 19041393]

Interaction Information:

Comment Tyrosine phosphorylated IRS1/2 recruit the heterodimeric p85/p110 PI3K at the plasma membrane, where it produces the lipid second messenger PIP3, which in turn activates a serine/threonine phosphorylation cascade of PH-domain containing proteins.
Formal Description
Interaction-ID: 5941

protein modification

IRS1-phosTyr

increases_activity of

complex/PPI

Phosphatidylinositol 3-kinase