General Information:

Id: 952 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Han W and Li C(2010) Linking type 2 diabetes and Alzheimers disease Proc. Natl. Acad. Sci. U.S.A. 107: 6557-6558 [PMID: 20385830]

Interaction Information:

Comment Insulin and leptin regulate Abeta levels by modulating Abeta production via their actions on BACE and/or gamma-secretase, as well as by modulating Abeta degradation via Abeta-degrading enzymes, such as insulin-degrading enzyme.
Formal Description
Interaction-ID: 5822

gene/protein

LEP

affects_activity of

gene/protein

BACE1

Drugbank entries Show/Hide entries for BACE1