General Information:

Id: 947 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
SIRT1 LKO: liver-specific SIRT1 knockout mouse on the C57BL/6 background
article
Reference: Purushotham A et al.(2009) Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation Cell Metab. 4: 327-338 [PMID: 19356714]

Interaction Information:

Comment Infiltration of macrophages into tissues is a hallmark of local inflammation. Analysis of mRNA from livers of SIRT1 LKO mice revealed a 70-80% increase in macrophage markers, including macrophage inflammation protein (MIP1a).
Formal Description
Interaction-ID: 5884

gene/protein

SIRT1

affects_quantity of

gene/protein

CCL3

in liver; if SIRT1 is knocked out in liver