General Information:

Id: 947 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
SIRT1 LKO: liver-specific SIRT1 knockout mouse on the C57BL/6 background
article
Reference: Purushotham A et al.(2009) Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation Cell Metab. 4: 327-338 [PMID: 19356714]

Interaction Information:

Comment Cyp7A1, the rate-limiting enzyme involved in the conversion of cholesterol to bile acids, was decreased in SIRT1 LKO mice on high-fat diet, suggesting that the accumulation of hepatic cholesterol may be the result of diminished bile synthesis.
Formal Description
Interaction-ID: 5855

gene/protein

SIRT1

affects_activity of

gene/protein

CYP7A1

in liver; on high-fat diet, if SIRT1 is knocked out in liver