General Information:
Id: | 947 (click here to show other Interactions for entry) |
Diseases: |
Diabetes mellitus, type II
- [OMIM]
Fatty liver disease, nonalcoholic Insulin resistance |
Mus musculus | |
SIRT1 LKO: liver-specific SIRT1 knockout mouse on the C57BL/6 background | |
article | |
Reference: | Purushotham A et al.(2009) Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation Cell Metab. 9: 327-338 [PMID: 19356714] |
Interaction Information:
Comment | Levels of PPAR-alpha targets known to regulate fatty acid oxidation were significantly lower in SIRT1 LKO mouse livers upon high-fat diet feeding: CPT1a, CPT2, ACAD, AOX, CD36, Cyp4A14, and Cyp4A10. |
Formal Description Interaction-ID: 5811 |
gene/protein affects_activity of process |