General Information:

Id: 947 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
SIRT1 LKO: liver-specific SIRT1 knockout mouse on the C57BL/6 background
article
Reference: Purushotham A et al.(2009) Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation Cell Metab. 9: 327-338 [PMID: 19356714]

Interaction Information:

Comment Levels of PPAR-alpha targets known to regulate fatty acid oxidation were significantly lower in SIRT1 LKO mouse livers upon high-fat diet feeding: CPT1a, CPT2, ACAD, AOX, CD36, Cyp4A14, and Cyp4A10.
Formal Description
Interaction-ID: 5811

gene/protein

SIRT1

affects_activity of

process

fatty acid beta-oxidation

in liver; on high-fat diet, if SIRT1 is knocked out in liver