General Information:

Id: 947 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
SIRT1 LKO: liver-specific SIRT1 knockout mouse on the C57BL/6 background
article
Reference: Purushotham A et al.(2009) Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation Cell Metab. 9: 327-338 [PMID: 19356714]

Interaction Information:

Comment Activation of PPAR-alpha by fasting promotes lipolysis in white adipose tissues and stimulates fatty acid oxidation and ketogenesis in the liver.
Formal Description
Interaction-ID: 5791

gene/protein

PPARA

increases_activity of

in liver
Drugbank entries Show/Hide entries for PPARA
Comment Levels of PPAR-alpha targets known to regulate fatty acid oxidation were significantly lower in SIRT1 LKO mouse livers upon high-fat diet feeding: CPT1a, CPT2, ACAD, AOX, CD36, Cyp4A14, and Cyp4A10.
Formal Description
Interaction-ID: 5811

gene/protein

SIRT1

affects_activity of

in liver; on high-fat diet, if SIRT1 is knocked out in liver
Comment To elucidate the regulatory role of SIRT1 in PPAR-alpha signaling in liver, primary hepatocytes from Lox control or SIRT1 LKO mice were treated with a PPAR-alpha agonist WY14643. WY treatment induced the expression of several genes involved in fatty acid oxidation in control hepatocytes. However, the induction of these genes was significantly lower in the SIRT1 deficient (LKO) hepatocytes.
Formal Description
Interaction-ID: 13194

gene/protein

PPARA

increases_activity of

in liver
Drugbank entries Show/Hide entries for PPARA
Comment To elucidate the regulatory role of SIRT1 in PPAR-alpha signaling in liver, primary hepatocytes from Lox control or SIRT1 LKO mice were treated with a PPAR-alpha agonist WY14643. WY treatment induced the expression of several genes involved in fatty acid oxidation in control hepatocytes. However, the induction of these genes was significantly lower in the SIRT1 deficient (LKO) hepatocytes.
Formal Description
Interaction-ID: 13195

gene/protein

SIRT1

affects_activity of

in liver; via PPARA