General Information:

Id: 947 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
SIRT1 LKO: liver-specific SIRT1 knockout mouse on the C57BL/6 background
article
Reference: Purushotham A et al.(2009) Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation Cell Metab. 9: 327-338 [PMID: 19356714]

Interaction Information:

Comment SIRT1 LKO mice displayed reduced expression of several PPAR-alpha target genes after overnight fasting: CPT1a, AOX, CD36, Cyp4A14, CytoC, and PGC-1a. Interestingly, the expression of PPAR-gamma co-activator 1-alpha (PGC-1alpha), a transcription co-factor known to activate PPAR-alpha, was also significantly lower in SIRT1 LKO mice.
Formal Description
Interaction-ID: 5768

gene/protein

SIRT1

affects_expression of

gene/protein

PPARGC1A

in liver; after overnight fasting, if SIRT1 is knocked out in liver
Comment SIRT1 interacts with PPAR-alpha and is required for the activation of PGC-1alpha.
Formal Description
Interaction-ID: 5788

gene/protein

SIRT1

increases_activity of

gene/protein

PPARGC1A

Comment Upon high-fat diet feeding a reduction in the expression of mitochondrial oxidative phosphorylation genes (Cytochrome C, Cox4 and Cox5b) was observed in livers of SIRT1 LKO mice. The decreased expression of the above-mentioned PPAR-alpha target genes was accompanied by a 40% decrease in the expression of PGC-1alpha mRNA.
Formal Description
Interaction-ID: 5850

gene/protein

SIRT1

affects_expression of

gene/protein

PPARGC1A

in liver; on high-fat diet, if SIRT1 is knocked out in liver