General Information:

Id: 947 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
SIRT1 LKO: liver-specific SIRT1 knockout mouse on the C57BL/6 background
article
Reference: Purushotham A et al.(2009) Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation Cell Metab. 4: 327-338 [PMID: 19356714]

Interaction Information:

Comment Quantitative real-time PCR (qPCR) confirmed decreased expression of several PPAR-alpha targets, including medium chain acyl-CoA dehydrogenase (MCAD), liver bifunctional enzyme (Ehhadh), palmitoyl acyl-CoA carboxylase (AOX), fatty acid transporter (CD36), and microsomal cytochrome P450 enzymes involved in the omega-oxidation of fatty acids (Cyp4A10 and Cyp4A14), in SIRT1 LKO mice compared to Lox controls. In contrast, the mRNA level of SPOT14, a gene known to be negatively regulated by PPAR-alpha, was significantly higher in the SIRT1 LKO mice.
Formal Description
Interaction-ID: 5756

gene/protein

SIRT1

affects_expression of

gene/protein

Cyp4A14

in liver; on chow diet, if SIRT1 is knocked out in liver