General Information:

Id: 947 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
SIRT1 LKO: liver-specific SIRT1 knockout mouse on the C57BL/6 background
article
Reference: Purushotham A et al.(2009) Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation Cell Metab. 4: 327-338 [PMID: 19356714]

Interaction Information:

Comment Although SIRT1 LKO mice showed no body weight abnormality on a chow diet, they gained significantly more weight than control mice on the western diet. Consistent with diet-induced obesity, SIRT1 LKO mice showed greater lipid accumulation in the liver compared to control mice. Their serum free fatty acid levels were also significantly increased as compared to control mice. Additionally, serum beta-hydroxybutyrate, a marker for fatty acid oxidation and ketogenesis in the liver, was significantly lower in the SIRT1 LKO mice.
Formal Description
Interaction-ID: 13198

gene/protein

SIRT1

affects_quantity of

drug/chemical compound

(R)-3-Hydroxybutanoate

in blood; if SIRT1 is knocked out in liver