General Information:

Id: 932 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
BTO:0003858 chondrocyte cell line; N1511 chondrocytes
article
Reference: Price J et al.(2010) Akt-1 mediates survival of chondrocytes from endoplasmic reticulum-induced stress. J. Cell. Physiol. 222: 502-508 [PMID: 20020442]

Interaction Information:

Comment Induction of ER stress (by using thapsigargin) in N1511 chondrocytes leads to an upregulation of BiP (HSPA5) after 18 h exposure.
Formal Description
Interaction-ID: 5635

increases_quantity of

gene/protein

HSPA5

Drugbank entries Show/Hide entries for HSPA5
Comment Induction of ER stress (by using thapsigargin) in N1511 chondrocytes leads to an upregulation of CHOP (DDIT3) after 6 h exposure.
Formal Description
Interaction-ID: 5640

increases_quantity of

gene/protein

DDIT3

Comment 4h after exposure to thapsigargin (induction of ER stress) Akt phosphorylation was detected. Akt phosphorylation remained elevated for 24 h.
Formal Description
Interaction-ID: 5641

increases_phosphorylation of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1