CIDeRGeneral Information:
| Id: | 918 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| article | |
| Reference: | Liu Y et al.(2008) A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 456: 269-273 [PMID: 18849969] |
Interaction Information:
| Comment | Hepatic SIRT1 protein accumulated after 18 h of fasting, when CRTC2 acetylation and protein amounts were correspondingly reduced. |
|
Formal Description Interaction-ID: 5660 |
|
| Comment | During prolonged fasting, SIRT1 deacetylates CRTC2 and promotes its ubiquitin-dependent degradation by COP1. |
|
Formal Description Interaction-ID: 5662 |
|
| Comment | During prolonged fasting, SIRT1 deacetylates CRTC2 and promotes its ubiquitin-dependent degradation by COP1. |
|
Formal Description Interaction-ID: 5667 |
|
| Comment | The reciprocal upregulation of FOXO1 activity by SIRT1 during prolonged fasting seems to be critical in maintaining energy balance through its effects on glucose metabolism. |
|
Formal Description Interaction-ID: 5669 |
|
| Comment | Disrupting SIRT1 activity, by liver-specific knockout of the Sirt1 gene or by administration of a SIRT1 antagonist, increased CRTC2 activity and glucose output, whereas exposure to SIRT1 agonists reduced them. |
|
Formal Description Interaction-ID: 5673 |
|
| Comment | Disrupting SIRT1 activity, by liver-specific knockout of the Sirt1 gene or by administration of a SIRT1 antagonist, increased CRTC2 activity and glucose output, whereas exposure to SIRT1 agonists reduced them. |
|
Formal Description Interaction-ID: 5727 |
|
| Comment | Disrupting SIRT1 activity, by liver-specific knockout of the Sirt1 gene or by administration of a SIRT1 antagonist, increased CRTC2 activity and glucose output, whereas exposure to SIRT1 agonists reduced them. |
|
Formal Description Interaction-ID: 5728 |
|