General Information:

Id: 918 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Liu Y et al.(2008) A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 456: 269-273 [PMID: 18849969]

Interaction Information:

Comment Hepatic SIRT1 protein accumulated after 18 h of fasting, when CRTC2 acetylation and protein amounts were correspondingly reduced.
Formal Description
Interaction-ID: 5660

environment

prolonged fasting

increases_quantity of

gene/protein

SIRT1

in liver
Comment During prolonged fasting, SIRT1 deacetylates CRTC2 and promotes its ubiquitin-dependent degradation by COP1.
Formal Description
Interaction-ID: 5662

gene/protein

SIRT1

decreases_acetylation of

gene/protein

CRTC2

during prolonged fasting
Comment During prolonged fasting, SIRT1 deacetylates CRTC2 and promotes its ubiquitin-dependent degradation by COP1.
Formal Description
Interaction-ID: 5667

gene/protein

SIRT1

decreases_quantity of

gene/protein

CRTC2

via ubiquitin-dependent degradation by COP1 during prolonged fasting
Comment The reciprocal upregulation of FOXO1 activity by SIRT1 during prolonged fasting seems to be critical in maintaining energy balance through its effects on glucose metabolism.
Formal Description
Interaction-ID: 5669

gene/protein

SIRT1

increases_activity of

gene/protein

FOXO1

during prolonged fasting
Comment Disrupting SIRT1 activity, by liver-specific knockout of the Sirt1 gene or by administration of a SIRT1 antagonist, increased CRTC2 activity and glucose output, whereas exposure to SIRT1 agonists reduced them.
Formal Description
Interaction-ID: 5673

gene/protein

SIRT1

affects_activity of

gene/protein

CRTC2

Comment Disrupting SIRT1 activity, by liver-specific knockout of the Sirt1 gene or by administration of a SIRT1 antagonist, increased CRTC2 activity and glucose output, whereas exposure to SIRT1 agonists reduced them.
Formal Description
Interaction-ID: 5727

gene/protein

SIRT1

affects_quantity of

drug/chemical compound

Glucose

Comment Disrupting SIRT1 activity, by liver-specific knockout of the Sirt1 gene or by administration of a SIRT1 antagonist, increased CRTC2 activity and glucose output, whereas exposure to SIRT1 agonists reduced them.
Formal Description
Interaction-ID: 5728

gene/protein

SIRT1

decreases_activity of

gene/protein

CRTC2