General Information:

Id: 918 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Liu Y et al.(2008) A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 456: 269-273 [PMID: 18849969]

Interaction Information:

Comment During prolonged fasting, SIRT1 deacetylates CRTC2 and promotes its ubiquitin-dependent degradation by COP1.
Formal Description
Interaction-ID: 5667

gene/protein

SIRT1

decreases_quantity of

gene/protein

CRTC2

via ubiquitin-dependent degradation by COP1 during prolonged fasting