General Information:

Id: 918 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Liu Y et al.(2008) A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 456: 269-273 [PMID: 18849969]

Interaction Information:

Comment RNAi-mediated depletion of hepatic CRTC2 reduced the gluconeogenic profile, which includes Ad-G6Pase-luc activity, gluconeogenic gene expression, and circulating blood glucose concentrations in short-term fasted mice, whereas depletion of FOXO1 had only modest effects at this time. In contrast, FOXO1 knockdown substantially reduced the gluconeogenic profile after 18 h of fasting, when CRTC2 was degraded.
Formal Description
Interaction-ID: 5577

gene/protein

FOXO1

increases_activity of

process

gluconeogenesis

in liver; after long-term fasting when CRTC2 is degraded