General Information:
Id: | 918 (click here to show other Interactions for entry) |
Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
Mus musculus | |
article | |
Reference: | Liu Y et al.(2008) A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 456: 269-273 [PMID: 18849969] |
Interaction Information:
Comment | RNAi-mediated depletion of hepatic CRTC2 reduced the gluconeogenic profile, which includes Ad-G6Pase-luc activity, gluconeogenic gene expression, and circulating blood glucose concentrations in short-term fasted mice, whereas depletion of FOXO1 had only modest effects at this time. In contrast, FOXO1 knockdown substantially reduced the gluconeogenic profile after 18 h of fasting, when CRTC2 was degraded. |
Formal Description Interaction-ID: 5577 |
gene/protein increases_activity of process |