General Information:

Id: 908 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Atherosclerosis
Parkinson disease
Mammalia
review
Reference: Sun AY et al.(2008) Botanical phenolics and brain health Neuromolecular Med. 10: 259-274 [PMID: 19191039]

Interaction Information:

Comment Curcumin can bind amyloid directly and inhibit Abeta aggregation.
Formal Description
Interaction-ID: 5543

drug/chemical compound

Curcumin

interacts (colocalizes) with

gene/protein

Amyloid beta peptide

and inhibits Abeta aggregation
Comment Curcumin can bind amyloid directly and inhibit Abeta aggregation as well as prevent fibril and oligomer formation.
Formal Description
Interaction-ID: 5544

drug/chemical compound

Curcumin

decreases_quantity of

Comment Both low and high doses of curcumin significantly lowered oxidized proteins and interleukin-1beta, a proinflammatory cytokine elevated in the brains of Tg2576 mice.
Formal Description
Interaction-ID: 5548

drug/chemical compound

Curcumin

decreases_quantity of

gene/protein

Oxidized protein

Comment Both low and high doses of curcumin significantly lowered oxidized proteins and interleukin-1beta, a proinflammatory cytokine elevated in the brains of Tg2576 mice.
Formal Description
Interaction-ID: 5549

drug/chemical compound

Curcumin

decreases_quantity of

gene/protein

IL1B

in brain; of Tg2576 mouse
Drugbank entries Show/Hide entries for IL1B
Comment Curcumin offers antioxidant, anti-inflammatory and cholesterol lowering properties, all are important on ameliorating the deleterious consequences of AD.
Formal Description
Interaction-ID: 5551

drug/chemical compound

Curcumin

decreases_activity of

Comment Curcumin offers antioxidant, anti-inflammatory and cholesterol lowering properties, all are important on ameliorating the deleterious consequences of AD.
Formal Description
Interaction-ID: 5557

drug/chemical compound

Curcumin

increases_activity of

Comment Neuroprotective effects of curcumin are known.
Formal Description
Interaction-ID: 5562

drug/chemical compound

Curcumin

increases_activity of

process

neuroprotection

Comment Curcumin can bind amyloid directly and inhibit Abeta aggregation as well as prevent fibril and oligomer formation.
Formal Description
Interaction-ID: 80156

drug/chemical compound

Curcumin

decreases_activity of

Comment Curcumin can bind amyloid directly and inhibit Abeta aggregation as well as prevent fibril and oligomer formation.
Formal Description
Interaction-ID: 80157

drug/chemical compound

Curcumin

decreases_quantity of

complex/PPI

Amyloid beta peptide (oligomer)