General Information:

Id: 908 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Atherosclerosis
Parkinson disease
Mammalia
review
Reference: Sun AY et al.(2008) Botanical phenolics and brain health Neuromolecular Med. 10: 259-274 [PMID: 19191039]

Interaction Information:

Comment Amyloid beta peptides can confer specific action on the N-methyl-D-aspartic acid (NMDA) receptors.
Formal Description
Interaction-ID: 5415

gene/protein

Amyloid beta peptide

affects_activity of

complex/PPI

NMDA receptor complex

Comment Abeta can induce ROS production in neurons through an NMDA receptor-dependent process.
Formal Description
Interaction-ID: 5419

gene/protein

Amyloid beta peptide

increases_quantity of

drug/chemical compound

Reactive oxygen species

in neuron; through an NMDA receptor-dependent process
Comment In astrocytes Abeta treatment was shown to cause the decrease in mitochondrial membrane potential, and this was partly due to activation of phospholipase.
Formal Description
Interaction-ID: 5420

gene/protein

Amyloid beta peptide

decreases_activity of

in astrocytes; partly due to activation of phospholipase
Comment Reveratrol is able to reduce Abeta secretion in several cell lines via a mechanism that involves the proteasome.
Formal Description
Interaction-ID: 5528

drug/chemical compound

Resveratrol

decreases_quantity of

gene/protein

Amyloid beta peptide

via a mechanism that involves the proteasome
Drugbank entries Show/Hide entries for Resveratrol
Comment Curcumin can bind amyloid directly and inhibit Abeta aggregation.
Formal Description
Interaction-ID: 5543

drug/chemical compound

Curcumin

interacts (colocalizes) with

gene/protein

Amyloid beta peptide

and inhibits Abeta aggregation