General Information:

Id: 908 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Atherosclerosis
Parkinson disease
Mammalia
review
Reference: Sun AY et al.(2008) Botanical phenolics and brain health Neuromolecular Med. 10: 259-274 [PMID: 19191039]

Interaction Information:

Comment Excess production of reactive oxygen species (ROS) in the brain has been implicated as a common underlying factor for the etiology of a number of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and stroke.
Formal Description
Interaction-ID: 5418

drug/chemical compound

Reactive oxygen species

increases_activity of

Comment Abeta can induce ROS production in neurons through an NMDA receptor-dependent process.
Formal Description
Interaction-ID: 5419

gene/protein

Amyloid beta peptide

increases_quantity of

drug/chemical compound

Reactive oxygen species

in neuron; through an NMDA receptor-dependent process
Comment Mitochondrial dysfunction is associated with increased production of ROS and release of cytochrome C, which in turn, triggers the apoptotic pathways.
Formal Description
Interaction-ID: 5421

drug/chemical compound

Reactive oxygen species

increases_activity of

in astrocytes
Comment Abeta-mediated ROS production is also linked to increased inflammatory responses, including increased production of cytokines, nitric oxide and eicosanoids.
Formal Description
Interaction-ID: 5423

drug/chemical compound

Reactive oxygen species

increases_activity of

in astrocytes; if ROS production is Abeta-induced
Comment Abeta-mediated ROS production is also linked to increased inflammatory responses, including increased production of cytokines, nitric oxide and eicosanoids.
Formal Description
Interaction-ID: 5430

drug/chemical compound

Reactive oxygen species

increases_activity of

in astrocytes; if ROS production is Abeta-induced
Comment Abeta-mediated ROS production is also linked to increased inflammatory responses, including increased production of cytokines, nitric oxide and eicosanoids.
Formal Description
Interaction-ID: 5432

drug/chemical compound

Reactive oxygen species

increases_activity of

in astrocytes; if ROS production is Abeta-induced
Comment Abeta-mediated ROS production is also linked to increased inflammatory responses, including increased production of cytokines, nitric oxide and eicosanoids.
Formal Description
Interaction-ID: 5435

drug/chemical compound

Reactive oxygen species

increases_activity of

in astrocytes; if ROS production is Abeta-induced
Comment Abeta-induced ROS from NADPH oxidase in astrocytes is a key factor in mediating neuronal death.
Formal Description
Interaction-ID: 5441

drug/chemical compound

Reactive oxygen species

increases_activity of

process

neuron death

in astrocytes; if ROS production is Abeta-induced
Comment Excess production of reactive oxygen species (ROS) in the brain has been implicated as a common underlying factor for the etiology of a number of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and stroke.
Formal Description
Interaction-ID: 10999

drug/chemical compound

Reactive oxygen species

increases_activity of

disease

Parkinson disease