General Information:

Id: 908
Diseases: Alzheimer disease - [OMIM]
Atherosclerosis
Parkinson disease
Mammalia
review
Reference: Sun AY et al.(2008) Botanical phenolics and brain health Neuromolecular Med. 10: 259-274 [PMID: 19191039]

Interaction Information:

Comment Increase in oxidative stress is associated with early development of Alzheimer's disease.
Formal Description
Interaction-ID: 5414

cooccurs with

phenotype

increased oxidative stress

Comment Amyloid beta peptides can confer specific action on the N-methyl-D-aspartic acid (NMDA) receptors.
Formal Description
Interaction-ID: 5415

gene/protein

Amyloid beta peptide

affects_activity of

complex/PPI

NMDA receptor complex

Comment One part of the oxidative mechanism affects the quantity of amyloid beta peptides (39-43 aa).
Formal Description
Interaction-ID: 5416

affects_quantity of

Comment Excess production of reactive oxygen species (ROS) in the brain has been implicated as a common underlying factor for the etiology of a number of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and stroke.
Formal Description
Interaction-ID: 5418

drug/chemical compound

Reactive oxygen species

increases_activity of

Comment Abeta can induce ROS production in neurons through an NMDA receptor-dependent process.
Formal Description
Interaction-ID: 5419

gene/protein

Amyloid beta peptide

increases_quantity of

drug/chemical compound

Reactive oxygen species

in neuron; through an NMDA receptor-dependent process
Comment In astrocytes Abeta treatment was shown to cause the decrease in mitochondrial membrane potential, and this was partly due to activation of phospholipase.
Formal Description
Interaction-ID: 5420

gene/protein

Amyloid beta peptide

decreases_activity of

in astrocytes; partly due to activation of phospholipase
Comment Mitochondrial dysfunction is associated with increased production of ROS and release of cytochrome C, which in turn, triggers the apoptotic pathways.
Formal Description
Interaction-ID: 5421

drug/chemical compound

Reactive oxygen species

affects_activity of

in astrocytes
Comment Mitochondrial dysfunction is associated with increased production of ROS and release of cytochrome C, which in turn, triggers the apoptotic pathways.
Formal Description
Interaction-ID: 5422

affects_activity of

in astrocytes
Comment Abeta-mediated ROS production is also linked to increased inflammatory responses, including increased production of cytokines, nitric oxide and eicosanoids.
Formal Description
Interaction-ID: 5423

drug/chemical compound

Reactive oxygen species

increases_activity of

in astrocytes; if ROS production is Abeta-induced
Comment Abeta-mediated ROS production is also linked to increased inflammatory responses, including increased production of cytokines, nitric oxide and eicosanoids.
Formal Description
Interaction-ID: 5430

drug/chemical compound

Reactive oxygen species

increases_activity of

in astrocytes; if ROS production is Abeta-induced
Comment Abeta-mediated ROS production is also linked to increased inflammatory responses, including increased production of cytokines, nitric oxide and eicosanoids.
Formal Description
Interaction-ID: 5432

drug/chemical compound

Reactive oxygen species

increases_activity of

in astrocytes; if ROS production is Abeta-induced
Comment Abeta-mediated ROS production is also linked to increased inflammatory responses, including increased production of cytokines, nitric oxide and eicosanoids.
Formal Description
Interaction-ID: 5435

drug/chemical compound

Reactive oxygen species

increases_activity of

in astrocytes; if ROS production is Abeta-induced
Comment Abeta-induced ROS from NADPH oxidase in astrocytes is a key factor in mediating neuronal death.
Formal Description
Interaction-ID: 5441

drug/chemical compound

Reactive oxygen species

affects_activity of

process

neuron death

in astrocytes; if ROS production is Abeta-induced
Comment Neuroprotective effects of resveratrol are known.
Formal Description
Interaction-ID: 5512

drug/chemical compound

Resveratrol

increases_activity of

process

neuroprotection

Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol is found in a variety of plant species and is used to treat fevers, hyperlipidemia, atherosclerosis, and inflammation.
Formal Description
Interaction-ID: 5514

drug/chemical compound

Resveratrol

decreases_activity of

Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol is found in a variety of plant species and is used to treat fevers, hyperlipidemia, atherosclerosis, and inflammation.
Formal Description
Interaction-ID: 5515

drug/chemical compound

Resveratrol

decreases_activity of

phenotype

hyperlipidemia

Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol is found in a variety of plant species and is used to treat fevers, hyperlipidemia, atherosclerosis, and inflammation.
Formal Description
Interaction-ID: 5516

drug/chemical compound

Resveratrol

decreases_activity of

Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol is found in a variety of plant species and is used to treat fevers, hyperlipidemia, atherosclerosis, and inflammation.
Formal Description
Interaction-ID: 5517

drug/chemical compound

Resveratrol

decreases_activity of

Drugbank entries Show/Hide entries for Resveratrol
Comment Hypothesis: The multiple roles of resveratrol as an antioxidant and as a life-promoting agent make it an attractive candidate for treatment of neurodegenerative diseases.
Formal Description
Interaction-ID: 5518

none selected

Drugbank entries Show/Hide entries for or
Comment Several studies demonstrated the ability for resveratrol to protect neurons against Abeta induced toxicity.
Formal Description
Interaction-ID: 5519

drug/chemical compound

Resveratrol

decreases_quantity of

Drugbank entries Show/Hide entries for Resveratrol
Comment Red wine consumption significantly attenuated AD-type deterioration of spatial memory function and Abeta neuropathology in Tg2576 mice.
Formal Description
Interaction-ID: 5523

environment

Red wine consumption

decreases_activity of

in Tg2576 mouse
Comment Red wine consumption significantly attenuated AD-type deterioration of spatial memory function and Abeta neuropathology in Tg2576 mice.
Formal Description
Interaction-ID: 5526

environment

Red wine consumption

decreases_activity of

phenotype

amyloidosis

in Tg2576 mouse
Comment Hypothesis: There is evidence that resveratrol can inhibit formation and extension of Abeta fibrils and destabilize the fibrilized Abeta.
Formal Description
Interaction-ID: 5527

none selected

Drugbank entries Show/Hide entries for or
Comment Reveratrol is able to reduce Abeta secretion in several cell lines via a mechanism that involves the proteasome.
Formal Description
Interaction-ID: 5528

drug/chemical compound

Resveratrol

decreases_quantity of

gene/protein

Amyloid beta peptide

via a mechanism that involves the proteasome
Drugbank entries Show/Hide entries for Resveratrol
Comment A number of studies have demonstrated the ability of resveratrol to suppress neuroinflammatory responses, e.g., attenuating iNOS and COX-2 expression.
Formal Description
Interaction-ID: 5531

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

PTGS2

Drugbank entries Show/Hide entries for Resveratrol or PTGS2
Comment A number of studies have demonstrated the ability of resveratrol to suppress neuroinflammatory responses, e.g., attenuating iNOS and COX-2 expression.
Formal Description
Interaction-ID: 5536

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

NOS2

Drugbank entries Show/Hide entries for Resveratrol or NOS2
Comment Curcumin can bind amyloid directly and inhibit Abeta aggregation.
Formal Description
Interaction-ID: 5543

drug/chemical compound

Curcumin

interacts (colocalizes) with

gene/protein

Amyloid beta peptide

and inhibits Abeta aggregation
Comment Curcumin can bind amyloid directly and inhibit Abeta aggregation as well as prevent fibril and oligomer formation.
Formal Description
Interaction-ID: 5544

drug/chemical compound

Curcumin

decreases_quantity of

Comment Red wine consumption significantly attenuated AD-type deterioration of spatial memory function and Abeta neuropathology in Tg2576 mice.
Formal Description
Interaction-ID: 5546

environment

Red wine consumption

decreases_quantity of

in Tg2576 mouse
Comment Both low and high doses of curcumin significantly lowered oxidized proteins and interleukin-1beta, a proinflammatory cytokine elevated in the brains of Tg2576 mice.
Formal Description
Interaction-ID: 5548

drug/chemical compound

Curcumin

decreases_quantity of

gene/protein

Oxidized protein

Comment Both low and high doses of curcumin significantly lowered oxidized proteins and interleukin-1beta, a proinflammatory cytokine elevated in the brains of Tg2576 mice.
Formal Description
Interaction-ID: 5549

drug/chemical compound

Curcumin

decreases_quantity of

gene/protein

IL1B

in brain; of Tg2576 mouse
Drugbank entries Show/Hide entries for IL1B
Comment Curcumin offers antioxidant, anti-inflammatory and cholesterol lowering properties, all are important on ameliorating the deleterious consequences of AD.
Formal Description
Interaction-ID: 5551

drug/chemical compound

Curcumin

decreases_activity of

Comment Curcumin offers antioxidant, anti-inflammatory and cholesterol lowering properties, all are important on ameliorating the deleterious consequences of AD.
Formal Description
Interaction-ID: 5557

drug/chemical compound

Curcumin

increases_activity of

Comment Neuroprotective effects of curcumin are known.
Formal Description
Interaction-ID: 5562

drug/chemical compound

Curcumin

increases_activity of

process

neuroprotection

Comment Effects of common botanicals on Alzheimer disease.
Formal Description
Interaction-ID: 5743

environment

Vaccinium (blueberry plant) supplementation

affects_activity of

in Tg2576 mouse
Comment Effects of common botanicals on Alzheimer disease.
Formal Description
Interaction-ID: 5744

drug/chemical compound

Resveratrol

affects_activity of

in Tg2576 mouse
Drugbank entries Show/Hide entries for Resveratrol
Comment Effects of common botanicals on Alzheimer disease.
Formal Description
Interaction-ID: 5745

environment

Allium sativum (garlic) supplementation

affects_activity of

in Tg2576 and TgCRND8 mouse
Comment Effects of common botanicals on Alzheimer disease.
Formal Description
Interaction-ID: 5748

drug/chemical compound

Ginseng

affects_activity of

in Tg2576 mouse
Drugbank entries Show/Hide entries for Ginseng
Comment Effects of common botanicals on Alzheimer disease.
Formal Description
Interaction-ID: 5749

drug/chemical compound

Ginkgo biloba

affects_activity of

in Tg2576 and TgAPP/S1 mouse
Drugbank entries Show/Hide entries for Ginkgo biloba
Comment Effects of common botanicals on Alzheimer disease.
Formal Description
Interaction-ID: 5750

drug/chemical compound

Ginsenoside Rb1

affects_activity of

in mouse
Comment Effects of common botanicals on Alzheimer disease.
Formal Description
Interaction-ID: 5751

drug/chemical compound

Ginsenoside M1

affects_activity of

in mouse
Comment Effects of common botanicals on Alzheimer disease.
Formal Description
Interaction-ID: 5753

drug/chemical compound

Pomegranate

affects_activity of

in Tg2576 mouse
Comment One part of the oxidative mechanism affects the quantity of amyloid beta peptides (39-43 aa).
Formal Description
Interaction-ID: 10906

affects_quantity of

Comment Excess production of reactive oxygen species (ROS) in the brain has been implicated as a common underlying factor for the etiology of a number of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and stroke.
Formal Description
Interaction-ID: 10999

drug/chemical compound

Reactive oxygen species

increases_activity of

disease

Parkinson disease

Comment Curcumin can bind amyloid directly and inhibit Abeta aggregation as well as prevent fibril and oligomer formation.
Formal Description
Interaction-ID: 80156

drug/chemical compound

Curcumin

decreases_activity of

Comment Curcumin can bind amyloid directly and inhibit Abeta aggregation as well as prevent fibril and oligomer formation.
Formal Description
Interaction-ID: 80157

drug/chemical compound

Curcumin

decreases_quantity of

complex/PPI

Amyloid beta peptide (oligomer)