General Information:

Id: 906 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
SirT1 ASO: knockdown of SirT1 expression in liver and adipose tissue, diabetic via initial streptozotocin injection and 4 weeks of fructose- and high-fat-feeding
article
Reference: Erion DM et al.(2009) SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proc. Natl. Acad. Sci. U.S.A. 106 [PMID: 19549853]

Interaction Information:

Comment SirT1 ASO decreases transcription of key gluconeogenic enzymes. The decreased gluconeogenetic gene expression from SirT1 knockdown differs from other reports, possibly because of the length of fasting.
Formal Description
Interaction-ID: 5486

gene/protein

SIRT1

affects_activity of

process

gluconeogenesis

if SIRT1 is knocked down in liver and adipose tissue of diabetic rats