General Information:

Id: 906 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
SirT1 ASO: knockdown of SirT1 expression in liver and adipose tissue, diabetic via initial streptozotocin injection and 4 weeks of fructose- and high-fat-feeding
article
Reference: Erion DM et al.(2009) SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proc. Natl. Acad. Sci. U.S.A. 106 [PMID: 19549853]

Interaction Information:

Comment SirT1 ASO increased STAT3 acetylation more than two-fold over control ASO-treated rats and STAT3 phosphorylation (Y705) more than three-fold compared with control ASO-treated rats.
Formal Description
Interaction-ID: 5475

gene/protein

SIRT1

affects_phosphorylation of

gene/protein

STAT3

if SIRT1 is knocked down in liver and adipose tissue of diabetic rats