General Information:

Id: 906 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
SirT1 ASO: knockdown of SirT1 expression in liver and adipose tissue, diabetic via initial streptozotocin injection and 4 weeks of fructose- and high-fat-feeding
article
Reference: Erion DM et al.(2009) SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proc. Natl. Acad. Sci. U.S.A. 106 [PMID: 19549853]

Interaction Information:

Comment In contrast to previous reports, Cyp7A1 transcription was upregulated with SirT1 ASO, indicating greater bile acid synthesis.
Formal Description
Interaction-ID: 5457

gene/protein

SIRT1

affects_expression of

gene/protein

CYP7A1

if SIRT1 is knocked down in liver and adipose tissue of diabetic rats