General Information:

Id: 906 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
SirT1 ASO: knockdown of SirT1 expression in liver and adipose tissue, diabetic via initial streptozotocin injection and 4 weeks of fructose- and high-fat-feeding
Reference: Erion DM et al.(2009) SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proc. Natl. Acad. Sci. U.S.A. 106 [PMID: 19549853]

Interaction Information:

Comment Additionally, the transcription of SirT1 in the hypothalamus was measured as a possible explanation for the decreased food intake and no differences in mRNA were found on the normal chow diet.
Formal Description
Interaction-ID: 5427

organism model

SirT1 ASO rat

NOT decreases_expression of



in hypothalamus