General Information:

Id: 904 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
BAC-based transgenic Sirt1 mouse with moderate overexpression of Sirt1
article
Reference: Pfluger PT et al.(2008) Sirt1 protects against high-fat diet-induced metabolic damage. Proc. Natl. Acad. Sci. U.S.A. 105: 9793-9798 [PMID: 18599449]

Interaction Information:

Comment In agreement with the observed Sirt1-mediated protection from hepatosteatosis, the authors found that Sirt1 transgenic mice presented lower levels of SREBP1c mRNA in response to high-fat diet.
Formal Description
Interaction-ID: 5382

gene/protein

SIRT1

affects_expression of

mRNA/protein variant

SREBF1c

in response to high-fat diet, if SIRT1 is overexpressed