General Information:

Id: 904 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
BAC-based transgenic Sirt1 mouse with moderate overexpression of Sirt1
article
Reference: Pfluger PT et al.(2008) Sirt1 protects against high-fat diet-induced metabolic damage. Proc. Natl. Acad. Sci. U.S.A. 105: 9793-9798 [PMID: 18599449]

Interaction Information:

Comment Neither plasma leptin levels nor adiponectin levels differed between genotypes on either SD or HFD.
Formal Description
Interaction-ID: 5373

gene/protein

SIRT1

NOT affects_quantity of

gene/protein

LEP

in blood; on standard diet, on high-fat diet, if SIRT1 is overexpressed