General Information:

Id: 904 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
BAC-based transgenic Sirt1 mouse with moderate overexpression of Sirt1
article
Reference: Pfluger PT et al.(2008) Sirt1 protects against high-fat diet-induced metabolic damage Proc. Natl. Acad. Sci. U.S.A. 105: 9793-9798 [PMID: 18599449]

Interaction Information:

Comment In addition to the reduced expression of inflammatory cytokines, the expression of the antioxidant proteins manganese superoxide dismutase (MnSOD) and the nuclear respiratory factor 1 (Nrf1), a master regulator in the protection from reactive oxygen species, were both increased in transgenic mice on both standard diet and high-fat diet, compared with wild-type mice. Both genes, MnSOD and Nrf1, have been demonstrated to be induced by PGC1alpha, which in turn is positively regulated by Sirt1.
Formal Description
Interaction-ID: 13192

gene/protein

SIRT1

increases_activity of

gene/protein

PPARGC1A

on standard diet, on high-fat diet, if SIRT1 is overexpressed