CIDeRGeneral Information:
| Id: | 900 (click here to show other Interactions for entry) |
| Diseases: |
Glioblastoma
Parkinson disease |
| Homo sapiens | |
| DBTRG cell, derived from human glioblastoma multiforma tumor | |
| article | |
| Reference: | Veeriah S et al.(2010) Somatic mutations of the Parkinsons disease-associated gene PARK2 in glioblastoma and other human malignancies. Nat. Genet. 42: 77-82 [PMID: 19946270] |
Interaction Information:
| Comment | Transfection of WT but not mutant PARK2 into cells from the DBTRG line resulted in a reduction in the rate of cell growth. WT PARK2 decreased tumor growth in vivo, a property that was reduced by the cancer-specific mutations. |
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Formal Description Interaction-ID: 5319 |
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