General Information:

Id: 900 (click here to show other Interactions for entry)
Diseases: Glioblastoma
Parkinson disease
Homo sapiens
DBTRG cell, derived from human glioblastoma multiforma tumor
article
Reference: Veeriah S et al.(2010) Somatic mutations of the Parkinsons disease-associated gene PARK2 in glioblastoma and other human malignancies. Nat. Genet. 42: 77-82 [PMID: 19946270]

Interaction Information:

Comment Transfection of WT but not mutant PARK2 into cells from the DBTRG line resulted in a reduction in the rate of cell growth. WT PARK2 decreased tumor growth in vivo, a property that was reduced by the cancer-specific mutations.
Formal Description
Interaction-ID: 5319

gene/protein

PARK2

decreases_activity of

in cancer cells