General Information:

Id: 897 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
article
Reference: Milne JC et al.(2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450: 712-716 [PMID: 18046409]

Interaction Information:

Comment In genetically obese Zucker fa/fa rats, hyperinsulinaemic-euglycaemic clamp studies demonstrate that SIRT1 activators (SRT1720) improve whole-body glucose homeostasis and insulin sensitivity in adipose tissue, skeletal muscle and liver.
Formal Description
Interaction-ID: 5331

gene/protein

SIRT1

decreases_activity of

disease

Insulin resistance

in adipose tissue, in skeletal muscle, in liver; in Zucker fa/fa rats