General Information:

Id: 897 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
article
Reference: Milne JC et al.(2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450: 712-716 [PMID: 18046409]

Interaction Information:

Comment To study SRT1720 in a genetic model of type 2 diabetes, Lep ob/ob mice were placed on a high-fat diet to induce a diabetic state and then dosed with SRT1720. SRT1720 treatment significantly reduced fasting blood glucose to near normal levels after 1 week.
Formal Description
Interaction-ID: 5320

gene/protein

SIRT1

decreases_quantity of

drug/chemical compound

Glucose

in blood; in diabetic Lep ob/ob mice