General Information:

Id: 897 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
article
Reference: Milne JC et al.(2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450: 712-716 [PMID: 18046409]

Interaction Information:

Comment In diet-induced obesity (DIO) mice SRT1720 significantly reduced the hyperinsulinemia after 4 weeks, but it did not reduce the insulin levels in mice fed a normal chow diet that are not insulin resistant.
Formal Description
Interaction-ID: 5314

gene/protein

SIRT1

decreases_activity of

in diet-induced obesity mice