General Information:

Id: 897 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
article
Reference: Milne JC et al.(2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450: 712-716 [PMID: 18046409]

Interaction Information:

Comment SRT501, a much less potent SIRT1 activator, also lowered fasting blood glucose in Lep ob/ob mice after 3 weeks (1,000 mg per kg (body weight)) and in DIO mice after 4 weeks (500 mg per kg (bodyweight)) of oral dosin.
Formal Description
Interaction-ID: 50433

drug/chemical compound

SRT501

increases_activity of

gene/protein

SIRT1