General Information:

Id: 892 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Neurological
Mammalia
BTO:0000567 HeLa cell
article
Reference: Uemura A et al.(2009) Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response. J. Cell. Sci. 122: 2877-2886 [PMID: 19622636]

Interaction Information:

Comment Thapsigargin induces ER stress.
Formal Description
Interaction-ID: 5260

drug/chemical compound

Thapsigargin

increases_activity of

Comment In the absence of ER stress, only XBP1(U) mRNA (unspliced XBP1 mRNA) was found in both soluble and insoluble fractions. When cells were treated with thapsigargin for 8 hours, the amount of XBP1(S) mRNA (spliced XBP1 mRNA) was increased by transcriptional induction in response to ER stress, and there was an increase of XBP1(S) mRNA fractionated into the soluble fraction.
Formal Description
Interaction-ID: 5261

increases_expression of

gene/protein

XBP1

XBP1(S) mRNA (spliced XBP1 mRNA)