General Information:

Id: 889 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
PGC-1beta ASO: knockdown of expression of PGC-1beta using antisense ologonucleotides (ASO)
article
Reference: Nagai Y et al.(2009) The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance. Cell Metab. 9: 252-264 [PMID: 19254570]

Interaction Information:

Comment PGC-1beta ASO increased insulin-stimulated whole-body glucose disposal due to a threefold increase in glucose uptake in white adipose tissue.
Formal Description
Interaction-ID: 5301

gene/protein

PPARGC1B

affects_activity of

process

glucose import

in white adipose tissue; stimulated by insulin, if PPARGC1B expression is knocked down