General Information:

Id: 889 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
PGC-1beta ASO: knockdown of expression of PGC-1beta using antisense ologonucleotides (ASO)
Reference: Nagai Y et al.(2009) The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance. Cell Metab. 9: 252-264 [PMID: 19254570]

Interaction Information:

Comment Hepatic de novo lipogenesis and hepatic triglyceride synthesis induced by fructose are both decreased by PGC-1beta ASO treatment.
Formal Description
Interaction-ID: 5297



affects_activity of

in liver; induced by fructose, if PPARGC1B expression is knocked down