General Information:

Id: 889 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
PGC-1beta ASO: knockdown of expression of PGC-1beta using antisense ologonucleotides (ASO)
article
Reference: Nagai Y et al.(2009) The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance. Cell Metab. 9: 252-264 [PMID: 19254570]

Interaction Information:

Comment PGC-1beta also induces mRNA expression of GLUT4 in cultures of primary rat skeletal muscle cells. In the present study, GLUT4 mRNA in WAT was decreased by 50% in PGC-1beta ASO-treated groups compared to wild-type mice. In contrast, the protein expression in both total tissue lysate and plasma membrane was increased 2-fold in only PGC-1beta ASO-treated high-fructose-fed rats, consistent with the result of 2-deoxyglucose uptake in WAT. There were no differences in the expression of other glucose transporters, GLUT1 and GLUT5 (known as a fructose transporter).
Formal Description
Interaction-ID: 5289

gene/protein

PPARGC1B

increases_expression of

gene/protein

SLC2A4

Comment Hepatic de novo lipogenesis and hepatic triglyceride synthesis induced by fructose are both decreased by PGC-1beta ASO treatment.
Formal Description
Interaction-ID: 5297

gene/protein

PPARGC1B

affects_activity of

in liver; induced by fructose, if PPARGC1B expression is knocked down