General Information:

Id: 889 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
PGC-1beta ASO: knockdown of expression of PGC-1beta using antisense ologonucleotides (ASO)
article
Reference: Nagai Y et al.(2009) The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance. Cell Metab. 9: 252-264 [PMID: 19254570]

Interaction Information:

Comment Compared with the rats fed high-fructose diet, the plasma glucose and insulin levels were significantly lower in PGC-1beta ASO-treated rats, 12% and 37%, respectively. The plasma triglyceride and leptin levels and epididymal fat mass were also significantly lower: 40%, 50%, and 13%, respectively. On the other hand, plasma concentrations of total cholesterol, HDL cholesterol, and beta-hydroxybutyrate were significantly higher in PGC-1beta ASO-treated rats: 58%, 63%, and 11%, respectively. Finally, there were no differences in plasma concentrations of glucagon, adiponectin, or retinol-binding protein 4 (RBP4).
Formal Description
Interaction-ID: 13151

gene/protein

PPARGC1B

affects_quantity of

gene/protein

LEP

in blood; if PPARGC1B expression is knocked down