General Information:

Id: 886 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Hara K et al.(2002) A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes Diabetologia 45: 740-743 [PMID: 12107756]

Interaction Information:

Comment A genetic variation in the PGC-1 gene was found to be associated with insulin resistance and susceptibility to Type II diabetes. Comparison of the frequencies of the Thr394Thr (ACG - ACA) - Gly482Ser haplotypes in the Type II diabetic subjects and the non-diabetic subjects revealed significantly different distribution of the haplotypes between Type II diabetic and non-diabetic subjects. The individual SNPs showed no significant association to Type II diabetes.
Formal Description
Interaction-ID: 5219

gene/protein mutant

PPARGC1A-p.T394T-G482S

increases_activity of