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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	886 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance
Organism:	Homo sapiens
Publication type:	article
Reference:	Hara K et al.(2002) A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes Diabetologia 45: 740-743 [PMID: 12107756]

Interaction Information:

Comment	A genetic variation in the PGC-1 gene was found to be associated with insulin resistance and susceptibility to Type II diabetes. Comparison of the frequencies of the Thr394Thr (ACG - ACA) - Gly482Ser haplotypes in the Type II diabetic subjects and the non-diabetic subjects revealed significantly different distribution of the haplotypes between Type II diabetic and non-diabetic subjects. The individual SNPs showed no significant association to Type II diabetes.
Formal Description Interaction-ID: 5219	gene/protein mutant PPARGC1A-p.T394T-G482S increases_activity of disease Diabetes mellitus, type II

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